The Pediatric Complex Care Association provides an opportunity for its member organizations to examine and discuss current evidence-based standards on key clinical issues with the goal of creating standardized approaches to care and practice.

The Association has produced the following Clinical Practice Guidelines:
- Multi-drug Resistant Organisms
- Pain Management
- Post-Acute Care Technology for the Child with Complex Medical Needs – Respiratory Care
- Enteral Feeding Devices
- Antimicrobial Stewardship
- Model Practice Guidelines
The Association plans to produce one Clinical Practice Guideline per year.
Through its Benchmarking Project, the Association has collected member data on pediatric clinical quality indicators since 2015. Dr. Haiyan Qu, a statistician from the University of Alabama, has analyzed this data and established a benchmark for each of the indicators.
